Seeing his brother crying, Bertie is deeply moved, puts a comforting hand on his shoulder. David pulls away as though touched by a leper and covers the receiver in his hand.
>> 国王的演讲 The King's Speech Movie Script

I'd rather have a lobotomy by a leper." That means something.
>> 心灵点滴 Patch Adams (1998) Movie Script

One minute, your best friend, the next, you're a leper.
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